The risks of thyroid dysfunction after iodinated contrast media (ICM) exposure are largely unknown, especially in Asian populations.
To determine whether ICM exposure in patients with normal thyroid would increase the risk of thyroid dysfunction, including hyperthyroidism or hypothyroidism.
Retrospective cohort study included a random selection of 1 million people in 2005.
General population in Taiwan Patients: Patients with ICM exposure were identified as cases, while patients without any ICM exposure were selected as controls.
ICM exposure or non-exposure in normal thyroid function patients.
The primary endpoint was the composite risk of thyroid dysfunction associated with ICM exposure.
A total of 19,642 cases and 78,568 matched controls were recruited in this study. The mean age of ICM exposure and non-exposure were 53.9 and 53.6 years old, and mean follow-up durations were 4.1 and 5.6 years, respectively. After adjustment, patients with ICM exposure had a significantly higher risk of thyroid dysfunction (HR 1.46, 95% CI 1.29-1.66). In the subgroup analysis, the adjusted hazard ratios of hyperthyroidism, and hypothyroidism compared with controls were 1.22 (95% CI 1.04-1.44), and 2.00 (95% CI 1.65-2.44), respectively.
ICM exposure was associated with higher risk of thyroid dysfunction, including hyperthyroidism and hypothyroidism.